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Ketamine HCl is a dissociative anesthetic that has some hallucinogenic effects.
It distorts perceptions of sight
and sound and makes the user feel disconnected and not in control. It is an injectable, short-acting anesthetic for use in humans and animals. It is referred to as a “dissociative anesthetic” because it makes patients feel detached from their pain and
Ketamine can induce a state of sedation (feeling calm and relaxed), immobility, relief from pain, and
amnesia (no memory of events while under the influence of the drug).
It is abused for its ability to produce dissociative
sensations and hallucinations. Ketamine has also been used to facilitate sexual assault.
Ketamine HCl comes in a clear liquid (LIQUID KETAMINE) and a white or off-white powder (Powdered ketamine HCl (100 milligrams to 200 milligrams) typically is packaged in small glass vials, small plastic bags, and capsules as well as paper, glassine, or aluminum foil folds. Powdered ketamine HCl is cut into lines known as bumps and snorted, or it is smoked, typically in marijuana or tobacco cigarettes.
Liquid ketamine is injected or mixed into drinks. Ketamine HCl is found by itself or often in combination with MDMA, amphetamine, methamphetamine, or cocaine.
Common street names Of ketamine:
• Cat Tranquilizer, Cat Valium, Jet K, Kit Kat, Purple, Special K, Special La Coke, Super Acid, Super K, and Vitamin K
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Is ketamine legal in the states?
Since the 1970s, ketamine has been marketed in the United States as an injectable, short-acting
anesthetic for use in humans and animals.
In 1999, ketamine, including its salts, isomers, and salts of isomers, became a Schedule III non-narcotic substance under the Controlled Substances Act.
It currently has accepted medical uses for short-term sedation and anesthesia.
In addition, in 2019, FDA approved the S enantiomer of ketamine (esketamine) nasal spray version (Spravato®) for treatment-resistant depression that is only available at a certified doctor’s office or clinic.
Ketamine has the potential for abuse, which may lead to moderate or low physical dependence or high psychological dependence.
Why is Ketamine Used Medically?
Ketamine can provide pain relief and short-term memory loss (for example, amnesia of a medical procedure).
In surgery, it is used as an induction and maintenance agent for sedation and to provide general anesthesia.
It has also been used for pain control in burn therapy, battlefield injuries, and in children who cannot use other anesthetics due to side effects or allergies.
How is Ketamine Abused?
In addition to its legal, medical uses, ketamine and synthesized analogs have become drugs of abuse with hallucinogenic properties.
It has also been used as a “date rape” drug.
When abused, it is typically insufflated (“snorted” up the nose) in social situations.
It is also injected, consumed orally as a liquid, or smoked in marijuana or tobacco.
It is frequently abused in combination with other substances, such as cocaine or amphetamines. Use with multiple drugs has been fatal.
When misused, it is often sourced via the illegal diversion of prescription products, but analogs may be found on the streets.
How Quickly Does Liquid ketamine Ketamine Work?
An injection yields a quick response, with effects occurring in seconds to minutes.
“Snorting” leads to effects in roughly 5 to 15 minutes (this is the most common method of abuse).
Oral consumption requires between 5 and 30 minutes.
The effects of abuse typically last 1 to 2 hours, but the user’s judgment, senses, and coordination may be affected for up to 24 hours or longer. Sensations the user may seek include floating, stimulation, and visual effects.
High doses may dangerously reduce breathing, lead to muscle spasms or weakness, dizziness, balance difficulty, impaired vision, slurred speech, nausea and vomiting, and severe confusion.
Dissociative drugs can lead to distortion of sights, colors, sounds, self, and one’s environment.
Ketamine is available in a clear liquid or off-white powder form for intravenous injection or as a nasal spray. Examples of other dissociative drugs include phencyclidine (PCP) and dextromethorphan (DXM).
In the U.S., ketamine is classified as a schedule III drug under the DEA Controlled Substances Act; however, it is not classified as an opioid (narcotic) or barbiturate.
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Abuse of large doses can also lead to powerful visual hallucinations that are intensified by environmental stimuli.
Coma and deep unconsciousness can occur. When higher doses of ketamine are abused, or during emergence, it is reported to produce and vivid dreams and an “out-of-body”, “K-hole” or “near-death” hallucinogenic experience, often reported as terrifying (similar to a bad LSD trip).
In smaller doses, such as those typically used recreationally, Liquid ketamine can lead to various effects such as:
- feelings of calmness and relaxation, relief from pain
- depressed mental state
- the detached feeling from the body
- slurred speech
- diminished reflexes
- hallucinations lasting from 30 to 60 minutes
- nystagmus (repetitive, uncontrolled movements of the eyes).
Overdose of Liquid Ketamine
- With an overdose of ketamine, emergency care, such as 911, should be contacted immediately.
- There is no antidote for this drug. Overdose situations are treated with symptomatic and supportive care in the hospital setting. In the emergency department, adverse effects typically resolve in 1 to 3 hours.
- Benzodiazepines such as lorazepam may be used if needed for seizures, excitation, or muscle rigidity.
- Respiratory support is rarely needed, but assisted ventilation or supplemental oxygen may be required. Respiratory depression may be more likely if combined with sedatives.
- Those who abuse this drug should be referred for drug counseling.
Ketamine HCl is a nonbarbiturate general anesthetic chemically designated dl 2-(0-chlorophenyl)-2 (methylamino) cyclohexanone hydrochloride.
It is formulated as a slightly acid (pH 3.5-5.5) sterile solution for intravenous or intramuscular injection in concentrations containing the equivalent of either 10, 50, or 100 mg ketamine base per milliliter and contains not more than 0.1 mg per mL Phemerol® (benzethonium chloride) added as a preservative.
The 10 mg per mL solution has been made isotonic with sodium chloride.
Ketamine HCl is a rapid-acting general anesthetic producing an anesthetic state characterized by profound analgesia, normal pharyngeal-laryngeal reflexes, normal or slightly enhanced skeletal muscle tone, cardiovascular and respiratory stimulation, and occasionally a transient and minimal respiratory depression.
The mechanism of action is primarily due to the antagonism of N-methyl-D-aspartate (NMDA receptors) in the central nervous system.
Liquid Ketamine is a medication primarily used for starting and maintaining anesthesia.
Ketamine induces dissociative anesthesia, a trance-like state providing pain relief, sedation, and amnesia.
The distinguishing features of ketamine anesthesia are preserved breathing and airway reflexes stimulated heart function with increased blood pressure and moderate bronchodilation.
At lower, sub-anesthetic doses, ketamine is a promising agent for pain and treatment-resistant depression.
INDICATIONS AND USAGE of LIQUID KETAMINE
Liquid Ketamine is indicated as the sole anesthetic agent for diagnostic and surgical procedures that do not require skeletal muscle relaxation.
Liquid Ketamine is best suited for short procedures but it can be used, with additional doses, for longer procedures.
Liquid Ketamine is indicated for the induction of anesthesia prior to the administration of other general anesthetic agents.
Ketamine HCl is indicated to supplement low-potency agents, such as nitrous oxide.
CONTRAINDICATIONS OF Liquid KETAMINE
Liquid Ketamine is contraindicated in those in whom a significant elevation of blood pressure would constitute a serious hazard and in those who have shown hypersensitivity to the drug.
Cardiac function should be continually monitored during the procedure in patients found to have hypertension or cardiac decompensation.
Postoperative confessional states may occur during the recovery period.
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